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ea0063p12 | Adrenal and Neuroendocrine Tumours 1 | ECE2019

Combined autophagy and mTOR inhibition reduces cells proliferation and induces apoptosis in a lung carcinoid in-vitro model

Knigin Adi , Avniel-Polak Shani , Gross David J , Grozinsky-Glasberg Simona

Introduction: Treatment options for patients with metastatic lung carcinoids (LC) are limited. Everolimus (RAD001), an mTOR inhibitor (mTORi) which suppresses tumor cells growth & proliferation, appears to be efficient in these patients; however, it promotes autophagy, thereby paradoxically supporting tumor cell survival and development of drug-resistance. We have previously demonstrated in a BON1 pancreatic NEN model that adding chloroquine (CQ, an autophagy inhibitor) to...

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ea0081oc14.6 | Oral Communications 14: Late Breaking | ECE2022

Engaging the Endocannabinoid System in Neuroendocrine Neoplasms (NENs) potentiates treatment outcomes and null drug resistance

Avniel- Polak Shani , Polak David , Oleinikov Kira , Gross David J , Wald Ori , Izhar Uzi , Mazeh Haggi , Drier Yotam , Glasberg Simona

Introduction: Patients with unresectable NENs are offered a variety of non-curable therapeutic options, which eventually fail due to drug resistance. Increasing evidence suggest an anticancer trait of cannabinoids, via cellular pathways including mTOR, known to be associated with drug resistance development. Still, limited data exist on the anti-cancer effects of cannabinoids in NENs.Aims: To understand the possible anti-tumor role of the cannabinoids an...

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Endocrine Abstracts

Combined autophagy and mTOR inhibition reduces cells proliferation and induces apoptosis in a lung carcinoid in-vitro model

Engaging the Endocannabinoid System in Neuroendocrine Neoplasms (NENs) potentiates treatment outcomes and null drug resistance

BiosciAbstracts